Sermorelin Dosage & Reconstitution Guide
Research and educational use only — not medical advice, and not for human consumption. The figures below are summarized from public sources, product labeling, and community reports, and are not a prescription or a substitute for a qualified clinician.
Reconstitution
Sermorelin ships as a freeze-dried (lyophilized) powder that has to be mixed with bacteriostatic water before use. Draw 2 mL of bacteriostatic water into a syringe and add it to a 10 mg vial, letting the stream run down the inside wall of the glass rather than blasting the powder directly. Swirl gently — never shake — until the solution is clear, then keep it refrigerated.
Worked example. 2 mL into a 10 mg vial gives a concentration of 5 mg/mL (5000 mcg/mL). A 300 mcg dose then works out to 0.06 mL = 6 units on a U-100 insulin syringe. Scale the water volume up or down to make your target dose land on an easy-to-read mark (1 unit = 0.01 mL).
- Wipe both vial stoppers (peptide and bacteriostatic water) with an alcohol swab and let them dry.
- Draw 2 mL of bacteriostatic water into a syringe.
- Inject it slowly against the inside wall of the peptide vial.
- Swirl gently until fully dissolved; do not shake.
- Label the vial with the contents, concentration, and date, and store it in the refrigerator.
Dosing schedule
| Phase | Dose | Volume | Insulin units (U-100) | Notes |
|---|---|---|---|---|
| Weeks 1–2 | 200 mcg | 0.04 mL | 4 units | once nightly |
| Weeks 3–4 | 300 mcg | 0.06 mL | 6 units | once nightly |
| Weeks 5–6 | 400 mcg | 0.08 mL | 8 units | once nightly |
| Weeks 7+ | 500 mcg | 0.1 mL | 10 units | once nightly |
Timing & cycling
Inject on an empty stomach at bedtime so the release window lines up with the natural overnight GH pulse. Skip food (especially carbs) for 60–90 minutes beforehand.
Cycle length. 3–6 months is the span most protocols run; some switch to a 5-days-on / 2-off pattern for maintenance.
Storage & handling
Keep the lyophilized (unmixed) vial refrigerated at 2–8 °C (36–46 °F) in a dry, dark place — it tolerates short periods at room temperature during shipping. Once reconstituted, store it at 2–8 °C, never frozen, and use it within about 2–4 weeks (sooner if the solution turns cloudy or discolored). Swab the stopper before every draw and use a fresh needle each time.
Supplies you'll need
- Sermorelin vials — about 3 for an 8-week run at the upper dose
- Bacteriostatic water — 2 mL per vial (a 10–30 mL multi-dose bottle covers several vials)
- U-100 insulin syringes (0.3–0.5 mL / 30–50 unit barrels are easiest to read) — roughly 56 for 8 weeks, plus spares
- Alcohol swabs — one per injection and one per vial draw
- Sharps container for safe needle disposal
Key points
- Bedtime timing matters more here than with most peptides — dosing in the morning blunts the effect.
- Step the dose up only if the current level is well tolerated; sleep quality usually improves first, body-composition changes take 8–12+ weeks.
- A 30- or 50-unit insulin syringe makes the early 200 mcg doses easier to read.
What to monitor
IGF-1 every 4–8 weeks is the usual progress marker; long runs also warrant a thyroid panel.
Legal & prescription status
In the US it is not sold as a standard FDA-approved drug, but it has been available by prescription through compounding pharmacies and telehealth clinics. The versions sold on research-chemical sites are unapproved and labelled 'not for human consumption.' (Note: FDA guidance on which peptides compounding pharmacies may prepare has tightened — availability changes over time.)
References
This guide is for research and educational purposes only. It is not medical advice and does not describe a product approved for human use. Always consult a qualified healthcare professional before considering any peptide protocol.