PE-22-28 Dosage & Reconstitution Guide
⚠ No validated or tested human dose exists. The published work is rodent-only, using intraperitoneal or intravenous delivery you cannot replicate at home.
Research and educational use only — not medical advice, and not for human consumption. The figures below are summarized from public sources, product labeling, and community reports, and are not a prescription or a substitute for a qualified clinician.
Dosing schedule
The table below reports the doses used in the underlying research or by the community — it is documentation, not a recommendation to replicate at home.
| Phase | Dose | Notes |
|---|---|---|
| Rodent studies | 1 mg | weight-scaled IP/IV in animals — not human-translatable |
Timing & cycling
Rodent studies used IP or IV injection; no human route or schedule is established.
Cycle length. None.
Storage & handling
Keep the lyophilized (unmixed) vial refrigerated at 2–8 °C (36–46 °F) in a dry, dark place — it tolerates short periods at room temperature during shipping. Once reconstituted, store it at 2–8 °C, never frozen, and use it within about 2–4 weeks (sooner if the solution turns cloudy or discolored). Swab the stopper before every draw and use a fresh needle each time.
Key points
- A spadin-derived peptide investigated for fast-acting antidepressant effects in mice.
- The gap between 'promising in rodents' and 'a number a person should inject' is the whole story here — we are not bridging it with a made-up dose.
What to monitor
No home markers exist for its target (TREK-1 channel modulation).
Legal & prescription status
No legal prescription exists. It is an unapproved research chemical, sold only for laboratory research and labelled 'not for human consumption.' It is not FDA-approved for any human use.
References
This guide is for research and educational purposes only. It is not medical advice and does not describe a product approved for human use. Always consult a qualified healthcare professional before considering any peptide protocol.