FOXO4-DRI Dosage & Reconstitution Guide
⚠ This is a senolytic studied only in mice. There is no validated, tested human dose — every figure below is a body-weight extrapolation from animal work, offered for context, not as a protocol.
Research and educational use only — not medical advice, and not for human consumption. The figures below are summarized from public sources, product labeling, and community reports, and are not a prescription or a substitute for a qualified clinician.
Dosing schedule
The table below reports the doses used in the underlying research or by the community — it is documentation, not a recommendation to replicate at home.
| Phase | Dose | Notes |
|---|---|---|
| Mouse model | 5 mg | ~5 mg/kg, 3 doses over ~1 week (animal, not human) |
Timing & cycling
Mouse studies dosed intermittently — several days on, then a gap — to let senescent cells clear between pulses, not daily.
Cycle length. The animal model used short pulsed courses, repeated periodically; no human cycle exists.
Storage & handling
Keep the lyophilized (unmixed) vial refrigerated at 2–8 °C (36–46 °F) in a dry, dark place — it tolerates short periods at room temperature during shipping. Once reconstituted, store it at 2–8 °C, never frozen, and use it within about 2–4 weeks (sooner if the solution turns cloudy or discolored). Swab the stopper before every draw and use a fresh needle each time.
Key points
- The FOXO4-DRI peptide disrupts the FOXO4–p53 interaction to push senescent cells into apoptosis.
- Because dosing is weight-scaled and pulsed in the only real data that exists, any fixed human number would be invented — we are not going to invent one.
What to monitor
There is no home marker for senescent-cell burden. This is the entry where 'wait for human trials' is the honest answer.
Legal & prescription status
No legal prescription exists. It is an unapproved research chemical, sold only for laboratory research and labelled 'not for human consumption.' It is not FDA-approved for any human use.
References
This guide is for research and educational purposes only. It is not medical advice and does not describe a product approved for human use. Always consult a qualified healthcare professional before considering any peptide protocol.