5-Amino-1MQ
Weight Loss · Weight Loss, Energy, Longevity
5-Amino-1MQ is a small-molecule inhibitor of the enzyme nicotinamide N-methyltransferase (NNMT), which is over-expressed in obese fat tissue and aging muscle. By blocking NNMT, it is studied for its potential to preserve cellular NAD+ and to increase energy expenditure in fat cells. It is a laboratory research compound taken orally and has not been tested in human clinical trials.
Research use only. Not for human consumption and not medical advice. Dosing figures are summarized from public sources and community reports, not clinical guidance.
Overview
5-Amino-1MQ (5-amino-1-methylquinolinium) is a small synthetic molecule rather than a peptide. It is studied as an inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that becomes over-active in obese fat tissue and aging skeletal muscle. Researchers are interested in whether blocking this enzyme can shift metabolism toward burning more energy.
Evidence Quality
All existing evidence comes from cell cultures and rodents. Several independent laboratories have reported consistent metabolic effects in mice, which is why the mechanism is taken seriously, but no human clinical trial, pharmacokinetic study, or bioavailability assessment has been published. Any human use is unvalidated extrapolation from animal data.
What the Research Shows
A 2014 Nature study found that knocking down NNMT protected mice from diet-induced obesity. Follow-up work in 2018 showed that small-molecule NNMT inhibitors reduced body weight and white fat mass in obese mice without reducing food intake. Later studies reported improved muscle stem-cell function in aged mice. The common thread is preserved NAD+ and SAM alongside increased cellular energy expenditure.
Dosage Notes
There is no clinically established human dose. Vendors and community guides commonly describe 50 to 150 mg taken orally per day, sometimes split into two doses and taken with food. These figures are derived from mouse studies using body-surface-area conversions, not from human trials, and should be treated as experimental.
Who Should Be Cautious
This compound is not appropriate for anyone who is pregnant, breastfeeding, or undergoing cancer treatment, given NNMT's links to cell metabolism and proliferation. Athletes subject to anti-doping rules should note it is not an approved supplement. Anyone with a medical condition or taking medication should not self-experiment without professional oversight.
Availability
5-Amino-1MQ is sold as a research chemical, typically as capsules or as powder in 5 mg and 50 mg vials for oral use. It is not FDA approved, is not a dietary supplement, and is not a prescription medication. Products are labeled for laboratory research only.
Bottom Line
The mechanism is scientifically interesting and the animal data are reasonably consistent, but 5-Amino-1MQ remains an early-stage research compound with no human evidence. Expectations should be modest and safety is unproven.
Reported effects
- Fat mass reduction: In obese mice, NNMT inhibition lowered body weight and white fat mass without changing how much the animals ate.
- Metabolic activation: Blocking NNMT preserved NAD+ and SAM in fat cells, which raised cellular energy expenditure in preclinical models.
- Muscle and aging signals: Aged-mouse studies reported improved muscle stem-cell activity and strength recovery, hinting at a broader metabolic role.
Reported side effects
- Digestive upset: Anecdotal user reports mention mild nausea or stomach changes, though no controlled human safety data exist.
- Headaches: Some people describe mild headaches early on, often attributed to hydration or the shift toward fat metabolism.
- Unknown long-term risks: With no human trials, long-term safety, drug interactions, and effects on the body's methylation balance are not established.
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